The score was based on genetic variants associated with the cumulative amount of GLP1R mRNA from a wide variety of tissue samples
Fat, or adipose cells, themselves secrete molecular signals that exert control over our blood sugar regulation, insulin sensitivity, appetite and inflammation
Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner (Meurot et al., 2022)
Research on protein metabolism suggests that consuming protein in evenly distributed doses throughout the day is more effective for maintaining lean mass than concentrating intake in one or two large meals
The challenges of achieving weight loss goals, and maintaining a healthy weight, are not unique to the GLP-1 phenomenon
- Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP-1, NEJM 2021, n=1,961) Jastreboff AM et al