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The underlying genetic defect involves the NF1 tumor suppressor gene, resulting in loss of neurofibromin, a protein responsible for regulating cell growth and preventing uncontrolled cell proliferation

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Ann Rheum Dis 68:10941099 Wahli W, Braissant O, Desvergne B (1995) Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis

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