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343 The additional unexpected observations from the GLP-1, GIP and GCGR tri-agonist studies 342,344 warrant further investigation, as these studies highlight the incomplete understanding of metabolic hormonal synergism, and that further elucidation of this will likely lead to more efficacious treatments for diseases such as T2D
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Melanotan II is a synthetic cyclic lactam analog of the naturally occurring alpha-melanocyte-stimulating hormone (-MSH)
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All three tirzepatide doses demonstrated superiority to semaglutide 1 mg for A1C reduction and non-inferiority was confirmed at every dose level
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