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This produces soluble factors which can induce demyelination or neurodegeneration either directly or indirectly through microglia activation (Lassmann, 2018)

Mutant IDH1 leads to the accumulation of the metabolite 2-hydroxyglutarate (2-HG), which stabilizes HIF-1, further promoting immune suppression in the TME

PubMed laboratory research record [PMID: 34829776] PubMed record related to this compound for laboratory literature review

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