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However, it: Only results in modest weight loss (~5-7% body weight) Can cause gastrointestinal distress (diarrhea, nausea) Works best for those with insulin resistance rather than general obesity How GLP-1 and GIP Medications Offer Superior Weight Loss GLP-1 (Glucagon-Like Peptide-1) and GIP (Gastric Inhibitory Polypeptide) receptor agonists represent a new era in obesity treatment , working through multiple mechanisms to promote substantial and sustainable weight loss : Enhanced Appetite Suppression and Fullness GLP-1/GIP medications mimic natural gut hormones that regulate hunger and satiety, leading to: Significantly reduced appetite and cravings Longer-lasting fullness after meals No stimulant effects or addiction potential More Effective Weight Loss Compared to older medications, GLP-1 and GIP drugs produce greater and sustained weight loss : Tirzepatide (Mounjaro/Zepbound): 20-25% total body weight loss Semaglutide (Ozempic/Wegovy): 15-20% total body weight loss Phentermine & Topamax (Qsymia): 5-10% weight loss Metformin: 5-7% weight loss Long-Term Safety and Cardiometabolic Benefits Unlike Phentermine, which is only approved for short-term use , GLP-1/GIP medications are safe for long-term weight management

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