From 2D to 3D: novel nanostructured scaffolds to investigate signalling in reconstructed neuronal networks
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But with aging, the immune system fails to clear these cells efficiently, and they accumulate in tissues throughout the body
Furthermore, mitochondrial ROS activate the NLRP3/caspase-1 axis, promoting IL-1 release and exacerbating emphysema [374]
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Plus, glutathione levels naturally decrease with age, and factors such as poor diet (alcohol, sugar and other processed foods) and sedentarism can furtter reduce glutathione levels