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Ozempic and Wegovy became cultural phenomena in 2023-2024, creating massive awareness of GLP-1 medications but also massive frustration with their cost ($1,000+ per month), injection format, and supply shortages
In the 1990s, researchers discovered that Gila monster saliva contains a peptide called exendin-4, which acts like GLP-1 but resists enzymatic breakdown
Nox family NADPH oxidases: molecular mechanisms of activation
"New Drug Therapy Approvals 2019"
American Journal of Physiology: Endocrinology and Metabolism, 282(2), 474-482
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