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But what does that mean

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They function similarly to a natural hormone produced by your body called GLP-1, short for glucagon-like peptide-1, which regulates blood sugar and hunger signals

Regulation of Cellular Functions This tripeptide is involved in regulating various cellular processes, including cell proliferation and apoptosis (programmed cell death)

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This means the peptide reaches peripheral GLP-1R in the gut and pancreas efficiently but enters the brainstem region that triggers nausea at lower concentrations