10.1016/S0022-3476(78)80305-9 40
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The gastrointestinal symptoms patients experience reflect the drugs' intended pharmacological effects on gut hormone signaling rather than cellular transformation or malignant changes
Ethics declarations Ethics approval All procedures, protocols, and medications were approved by the Johns Hopkins University Animal Care and Use Committee and were performed in accordance with the Association for Research in Vision and Ophthalmology statement for use of animals in ophthalmic and vision research, and the National Institutes of Health guide for the care and use of laboratory animals
While body weight and composition can influence drug distribution, the half-life of these specific medications is not significantly altered by body weight