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Safety and Regulatory Concerns Long-term use is restricted in many countries due to risks like skin thinning and rebound pigmentation

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Glutathione binds to toxins and, after extracellular breakdown, enters the bile or is excreted in the urine

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[25] The same Health Canada study referenced above found that "DEET was not found to be mutagenic, nor was it carcinogenic in either rats or mice." [26] The European Chemicals Agency (ECHA) has reviewed DEET and assigned classifications for acute toxicity, irritation, and environmental hazard onlyno carcinogenic, mutagenic, or reproductive toxicity hazards were identified