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Direct GPX4 activity targeting has the potential to trigger ferroptosis in cells [27]

Better measurement precision at a larger amount is not an argument for using a larger amount under a non-monotonic dose-response, a precisely measured wrong dose is still a wrong dose

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In triple-negative breast cancer (TNBC) cells treated with isorhamnetin (IH) and chloroquine (CQ), ROS induced Drp1-dependent mitochondrial fission and apoptosis by mediating the activation and mitochondrial translocation of CaMKII