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[10] The unpredictability of oral bioavailability in different people is also a reason for a medication to be administered IV, as with furosemide

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PMID 21639810

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Since its clinical application in 1957, metformins cornerstone status has remained consistent and it is still the first-line preferred treatment for type 2 diabetes mellitus (T2DM) side by side with lifestyle (Montvida et al., 2018