Serious side effects: have included pancreatitis, gallbladder disease, acute kidney injury, hypoglycemia, and severe allergic or injection-site reactions
Animal models, such as prenatal VPA exposure, replicate human symptoms and allow mechanistic studies (Schneider and Przewocki 2005
Lab studies have linked these drugs with thyroid tumors in rats
Known risks include multiple pregnancies (eg, twins or triplets) and related pregnancy complications, as well as side effects in the female partner when ovulation-inducing drugs are used
Your provider can review your progress, discuss side effect management, and help you decide whether adjusting your dose within the once-weekly framework, trying a different formulation, or exploring combination therapy makes sense for your goals
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