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While tirzepatide has yet to demonstrate direct cardiovascular risk outcomes in patients without type 2 diabetes, tirzepatide-treated groups did demonstrate reductions in cardiometabolic variables resulting in a significantly lower 10-year predicted ASCVD risk in patients with overweight or obesity without type 2 diabetes in post hoc analysis of the SURMOUNT-1 trial [49]

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reported a poor correlation between faecal and plasma metabolomics in patients with CRC, further highlighting that these methods capture distinct aspects of host-microbiome interactions 75