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Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: Implications for neurodegeneration in Alzheimers disease

Participants were randomized to placebo or one of five active doses: 1 mg, 4 mg, 8 mg, or 12 mg once weekly, with two titration schedules for the 8 mg group

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Other studies have reported that a reduction in hippocampal neurogenesis leads to an increase in anxiety symptoms and the onset of depression (Hanson et al., 2011