PMID: 26367736 [26] Dinkova-Kostova AT, Holtzclaw WD, Cole RN, et al
Do not change a dose because of social media advice, a weight-loss target, or a friends experience
Counterfeit medication: The FDA warns that counterfeit GLP-1 medicationscan containtoo much, too little, or none of their active ingredients
doi:10.3803/enm.2020.35.1.1
AMG 133 functionally inhibits GIP signalling through human and cynomolgus monkey GIPR with similar potency (half maximal inhibitory concentration (IC 50 ) of 42.4 nM and 26.5 nM, respectively), whereas it has more than 20-fold lower potency for inhibition of GIP signalling through rat GIPR (IC 50 = 822 nM) and did not fully antagonize mouse GIPR with concentrations of up to 3 M
However, these days, lots of people are using it in higher doses as a weight loss medication under the brand name Wegovy