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FDA identified possible immunogenicity risks from aggregation and peptide-related impurities and proposed not adding either defined TB-500 substance to the 503A Bulks List

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doi: 10.1053/j.gastro.2010.04.054 67 WooYCLeeCHFongCHYXuATsoAWKCheungBMYet al

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[4] Aging Endogenous GSH synthesis decreases with age due to decreased expression of glutamate cysteine ligase

Int J Biochem Cell Biol 1998