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The biology is too interconnected, the mechanisms too numerous, and the standard tools too blunt

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Nature 337 , 184187 (1989)

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In a subsequent study, lean Gipr AP-KO and Gipr AP-GFP mice were switched to an HFD on the same day as initiating 10 days of daily injections with either LIRA (or VEH) alone, or LIRA (or VEH) plus GIPR antagonist peptide (GIPR-antag) 6

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