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15:9 Method: Fasting for 15 hours an eating within 9-hour window

Methods Study subjects This study was approved by the Institutional Review Board of the Baylor College of Medicine Biomedical Research and Assurance Information Network (BRAIN) under protocol number H-31612

Contraindications and safety precautions Berberine should be used carefully, as it is not suitable for everyone and can interact with certain medicines

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Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

The truncated trial duration, MACE, and its individual components in the intervention and placebo arms were estimated