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In endothelial cell models, BPC-157 enhanced ERK1/2 phosphorylation in a dose-dependent manner, increasing cellular proliferation, migration, and vascular tube formation via downstream transcription factors c-Fos, c-Jun, and EGR-1
Important limitations on this safety profile: the longest trial was 24 weeks, the total trial population is small by modern standards, and the clinical trials used oral dosing
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Research has looked at its effects on muscle recovery, bone healing, and nerve repair
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