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Validated medical treatments are: Narrow-band UVB phototherapy (311 nm) the gold standard for extensive vitiligo Topical corticosteroids and calcineurin inhibitors (tacrolimus) applied topically The JAK inhibitors (ruxolitinib cream) recent innovation approved in 2022-2023 Melanocyte grafts for stabilized segmental forms The choice depends on the type of vitiligo, extent, age, and profile