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And perhaps most importantly, the rate of treatment discontinuation, which reveals how tolerable each treatment is in the real world rather than in the controlled environment of separate trials

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Despite initially promising results, SAR425899 has been discontinued after phase 2 trials showed treatment related gastrointestinal disorders (NCT03437720)

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J Magn Magn Mater 518:167436 DeKrafft KE, Boyle WS, Burk LM, Zhou OZ, Lin W (2012) Zr-and Hf-based nanoscale metalorganic frameworks as contrast agents for computed tomography