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[22] However, some endogenous compounds, e.g., bilirubin, can inhibit the activity of GSTs

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This dual mechanismboth substrate delivery and gene activationexplains the strong antioxidant effect of GHK-Cu, which exceeds what would be achievable through simple copper supplementation alone

However, more clinical studies must be encouraged to evaluate whether these drugs can act as GSH system enhancers and cardioprotective agents in patients