Complement activation, cytotoxicity, and alterations in cell junction proteins (e.g., reduced connexin-43) may also exacerbate tissue injury(Wroska et al., 2024)
Sappl et al., 2004, 2009)
Tosatto SCE, Bosello V, Fogolari F, et al
That's where high-protein meals like grilled chicken skewers come in
[31] A large study found that GLP-1 RA use was associated with lower risk of developing immune-mediated inflammatory diseases in patients with type 2 diabetes or obesity, suggesting a potential protective effect in some cohorts.[42] What the science is showing is potential for improvements: GLP-1RAs reduce blunt activation in fibroblast-like synoviocytes and improve joint inflammation and metabolic parameters in rheumatoid arthritis models and small human cohorts.[26][29][25] [31] Early clinical studies and case series in RA patients (especially those with coexisting type 2 diabetes or obesity) reported reduced disease activity scores (DAS28), lower C-reactive protein and erythrocyte sedimentation rate levels, fewer swollen joints, and diminished morning stiffness during GLP-1RA treatment, along with the expected weight reduction and improved insulin sensitivity.[31] Psoriasis showed improved PASI scores and quality-of-life metrics in patients with T2DM and psoriasis, alongside reductions in lesional skin and peripheral TNF-producing monocytes.[26] Case series show meaningful skin improvement.[26] In psoriasis and psoriatic arthritis , GLP-1RA therapy has been associated with improvements in inflammatory markers and disease severity indices
ACC1 can be phosphorylated by AMP-activated protein kinase (AMPK), which inhibits its enzymatic activity, thus restraining the generation of fatty acids, particularly PUFAs, finally resulting in insensitivity to ferroptosis [95]
