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In contrast, only 3 extracellular metabolites, 2-isopropylmalate, 4-aminobenzoate, and glutamate, showed significant differences between wild-type and gdh3 / gdh3 strains cultured on arginine medium

10.3390/nu13082750 51 TakayaK.SuzukiT.MotohashiH.OnoderaK.SatomiS.KenslerT

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Strategies aimed at disrupting lactate-mediated ferroptosis resistance in tumors while reducing lactate-mediated ferroptosis in sepsis may offer selective therapeutic windows