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The IGF-1 axis benefits from the same pause: it drifts back toward baseline instead of sitting chronically elevated, which is the safer position given GH/IGF-1s growth-promoting signaling

[PubMed: 16195500] 4

Endurance Athletes (Distance Running, Cycling, Triathlon, Rowing, Cross-Country Skiing) The biggest practical challenges are gastrointestinal and fueling related: Delayed gastric emptying can increase the risk of acid reflux, bloating, or side-stitch during hard efforts if large meals or gels are consumed too close to training

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As with pregnancy, an alternative preservative-free diluent may be preferred for nursing mothers if feasible