In non-enzymatic processes, the H 2 O 2 combines with Fe 2+ (e.g., ferritin protein) or Cu 2+ (e.g., ceruplasmin protein) ions in the Fenton reaction, where it accepts an electron from metal ions to form highly reactive (t 1/2 = 10 9 s) HO radical and HO + ion and thus are highly reactivity in the mitochondrial matrix [16]
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Pharmacologic GLP-1 receptor activation improves glucose homeostasis through glucose-dependent insulin secretion, suppression of inappropriate glucagon secretion, delayed gastric emptying, and reduced appetite
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