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These doses sit well within the range tested in animal safety studies and far below levels where any toxicity was observed
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These results suggest that the downregulation of GPX4 contributes to MI-induced ferroptosis
The simulated profiles for the reduced and comproportionation models, as well as the parameter values generated from the fitting process, are located in the supplementary information
In the electron transport chain (ETC), FMN and FAD function as cofactors that shuttle electrons, acting especially in I and II complexes, which contain flavoproteins reductases and electron transferring flavoproteins, thereby facilitating the production of adenosine triphosphate (ATP), the primary energy source of cells, being particularly important in the nervous system, due to its high energy demands (43, 45)
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