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AOD-9604 achieves selective fat metabolism by targeting beta-3 adrenergic receptors in adipose tissue without binding to growth hormone receptors that mediate IGF-1 production, glucose metabolism, and tissue growth

Dual agonists (e.g., Tirzepatide): Act on both GLP-1 and GIP receptors to more vigorously improve blood sugar control and weight loss

For example, in the STEP 1 trial , patients taking semaglutide lost an average of 14.9% of their body weight over 68 weeks , compared with just 2.4% in the placebo group (NEJM study)

Researchers investigate how selective NNMT inhibition affects cellular processes under controlled laboratory conditions