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Studies are now ongoing to assess the cost-effectiveness and long-term implications of incorporating GLP-1 agonists into the treatment landscape of bipolar disorder

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Clinicians should consider the following factors: Diagnosis of type 2 diabetes, confirmed without autoimmune markers Failure to achieve glycemic control with lifestyle changes and metformin Obesity (BMI 95th percentile for age and sex) A supportive family environment and readiness to adhere to treatment Early discussions about the role of GLP1 therapy help align expectations and clarify both risks and benefits

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