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Exposure to high glucose triggers rapid posttranslational hydroxylation and degradation of hypoxia-inducible factor-1alpha

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(PubMed) Sawicka AK, Hartmane D, Lipinska P, Wojtowicz E, Lysiak-Szydlowska W, Olek RA

The cultured SGNs were exposed to 100 M peroxynitrite for 48 h (Figure 2C) and immunostaining illustrated that the fluorescence intensity of GPX1 in the peroxynitrite group was significantly reduced compared with that of the control group (Figure 2D)