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SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose

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Peptides have existed as potential drug candidates for decades, but the process of linking the amino acids in the correct sequence requiring repeated chemical reactions and purification made them difficult to manufacture and incredibly labor-intensive, Kates said

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Tissue preparation and metabolite extraction Mice were deeply anesthetized with intraperitoneal injection of Ketamine (90 mg/kg, and Xylazine (10 mg/kg