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These effects can counteract medication benefits

Why Weight Gain Feels Different During Menopause Many women notice that weight becomes harder to manage during perimenopause and menopause, even if their eating habits have not changed dramatically

Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF

Clin Chem 63(2):464

Thymosin Beta-4 was originally identified as a thymic hormone involved in T-cell differentiation, but its functional significance is now understood to extend well beyond the immune system