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These unstable molecules can damage cells and contribute to ageing

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The outcome of corresponding or similar mutations in humans is described, as well as the potential mechanisms underlying increased longevity and the therapeutic benefits and risks of medical disruption of the GH/IGF-1 axis in humans

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The nail plate is a very hard tissue that is difficult to cut, and this often leads to tractional artefacts, epithelial detachments, and, ultimately, a poor orientation of the cut, thereby hindering interpretation.3,7,10,11,16 There are different methods for softening the nail piece before cutting,3,911,13,31 but these are outside the scope of the present article