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moreover, the pro-inflammatory mediators these cells secrete delay the phenotypic transformation of macrophages from M1 to M2, hinder the establishment of an anti-inflammatory microenvironment, and thereby promote fibrosis and ectopic ossification (116)

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The molecule makes three changes to the native hormone fragment: a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, inversion to D-phenylalanine at position 7, and substitution of norleucine for the oxidation-prone methionine at position 4

Rosenstock J, Allison D, Birkenfeld AL, et al

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