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Ideally, stay at a dose for six to eight weeks before escalating to fully assess its effect
Steady dose escalation to higher doses than for glycaemic control are indicated if: BMI is 30 kg/m 2 , or BMI 27 to 30 kg/m 2 , and for the range 2730 kg/m 2 if there is one weight-related comorbidity (hypertension, dyslipidaemia, cardiovascular disease, obstructive sleep apnoea, prediabetes or T2D
In addition, the Supporting Factors such as sleep and hydration will materially affect results
Throughout the experiment, mice had ad libitum access to food and water
The transition is not always smooth
Collectively, these actions address several of the metabolic consequences that estrogen withdrawal sets in motion, including worsening insulin resistance, dyslipidemia, and chronic low-grade inflammation
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