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There may be two different pathways, a mitochondrial-dependent and mitochondrial-independent pathways

Ethics, reproducibility and methodological pitfalls Frequent pitfalls in cognitive peptide research No vehicle control in some old Russian studies: mandatory in any modern publication Non-randomisation : assigning animals to groups by order of arrival introduces systematic bias (weight, oestral cycle, cage stress) Non-blinded experimenter : behavioural tests are highly sensitive to expectations

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Key Research Findings at a Glance Francis et al

As with any dietary supplement, those who are pregnant, nursing, taking medications, or managing a medical condition should consult a healthcare professional before use

Monitor symptoms through journaling and consider hormone testing to track progress objectively