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Research utilizing single-cell Raman microspectroscopy has demonstrated that ME/CFS patients exhibit significant aberrations in ROS clearance pathways, including elevated oxidative stress markers and reduced antioxidant enzyme activity

J Androl 13:450455 Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage

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4,811 However, patients with more benign reactions or a suspected IgE-mediated allergy may be candidates for reevaluation