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FIGURE 3 PEROXIREDOXINTHIOREDOXIN REDOX CYCLE Peroxiredoxins constitute a family of thiol-specific peroxidases that rely on thioredoxins (Trxs) as the hydrogen donor for the reduction of H 2 O 2 and lipid hydroperoxides ( 2 O 2 produced by the mitochondrial respiratory chain

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Age: Glutathione levels naturally decrease with age, which can impair detoxification, immunity, and antioxidant protection

In mitochondria, Ca 2+ can trigger apoptosis by opening the mitochondrial permeability transition pore (mPTP) [205, 206]

Cell 3 , 1111?1123 (2004)

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