21 These effects can lower nutrient absorption and prevent overnutrition directly related to T2D development and weight gain
Warning Signs to Watch For What to Do Before Starting Treatment What to Do During Treatment Potential Benefits Beyond the Eye Practical Patient Questions Related Reading Diabetic Eye Disease: The Complete Patient Guide Diabetic Retinopathy Stages Diabetic Macular Edema Diabetes Control and Eye Health Why Your Endocrinologist Matters in Diabetic Eye Disease Key Learning Points GLP-1 receptor agonists are useful diabetes medicines, but patients with diabetic retinopathy should not ignore eye monitoring
In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone
These results support important differences obtained by enzymatic inhibition versus complete deletion of the DPP4 protein
Potential limitations with real world studies of drug effects include the possibility of confounding and time related biases
But it does mean that side effects during the first week or two of a dose increase are not necessarily representative of what that dose feels like at steady state