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A deficiency of Vitamin B12 can lead to advanced anemia where the red cells are fewer in number but are larger than normal (macrocytic)

It is typically used to treat joint pain, arthritis, ligament and tendon injuries, post-surgical recovery, nerve problems, and digestive issues such as IBD or leaky gut

Weight-Adjusted Calculation Chart For those who prefer weight-based calculations, the following chart provides dosing ranges based on body weight using the common mcg/kg approach

The intranasal formulations are not approved to treat acute B12 deficiency

However, no human studies have examined truly long-term use extending over years or decades

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