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Notably, only a fraction of cancer cells needs to undergo pyroptosis to induce immune cell infiltration and antitumour immunity with tolerable toxicity
There are no studies indicating IV glutathione is bad for the kidney
It also offers anti-inflammatory, gut, and organ support
This established the modern theoretical framework of hormesis
Consequently, when Nrf2 signaling is blocked, these indirect bone-protective effects of metformin may be diminished or inconsistent, contributing to the observed variability in trabecular bone outcomes in Nrf2 KO mice
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