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The second stage consists of pathophysiological events caused by blood components and their metabolites, including BBB destruction, neural excitatory events, ion disturbances, oxidative stress, neuroinflammation, cell death, etc (Magid-Bernstein et al., 2022)

Prog Neuropsychopharmacol Biol Psychiatry (2010) 34:14.10.1016/j.pnpbp.2009.11.009 135 MasakiTChibaSYasudaTNoguchiHKakumaTWatanabeTet alInvolvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity

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