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Yet, it is important to consider that the highest quality trial lasted only one week and was conducted in patients recovering from abdominal surgery [9]
Similar anti-fibrotic effects of liraglutide have been reported in a streptozotocin (STZ)-induced diabetic model, where liraglutide reduced -SMA, collagen I and fibronectin expression and altered the renal proteome consistent with decreased oxidative stress and attenuated ECM deposition [57]
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It helps control blood sugar levels by increasing insulin release and decreasing glucagon release
GAP-43 is a presynaptic secreted protein highly expressed during neuronal development and synaptogenesis in the hippocampus and the related cortices [49,50,51,52]
Further defining the commonalities and differences between GLP-1R agonists and bariatric surgery in terms of how they target the brain may not only help bridge the gap between pharmacological and surgical interventions for weight loss but also provide a neural basis for their combined use when each individually fails
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