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[1] In phase 3 trials, orforglipron produced 12.4% weight loss (27.3 lbs) at 72 weeks less than injectable tirzepatide (20%) but comparable to oral semaglutide

While rare, these symptoms could indicate a serious cardiovascular reaction or another unrelated medical issue requiring urgent care

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3 Because postprandial hyperglycemia affects A1C to a greater degree than fasting hyperglycemia, the closer a patient is to the A1C goal, GLP-1 receptor agonists provide a viable treatment option to target postprandial glucose excursions due to their glucose-dependent effects on insulin secretion