After four years of following patients, the select trial revealed how quickly it works, if patients keep the weight off and something else surprising
This may take 4-6 months
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Common adverse effects , particularly during dose escalation, include: Nausea (reported by 2050% of patients, usually mild to moderate) Vomiting, diarrhoea, or constipation Abdominal discomfort or bloating Reduced appetite (therapeutic effect, but may feel unusual initially) Fatigue or headache These effects typically diminish over several weeks as tolerance develops
These findings indicate a bidirectional hostmicrobial signaling that regulates gut microbiota colonization via the serotonergic system
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