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Sublingual sprays or transdermal patches must be developed to make them realistic in clinical workflows

The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements

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Human Skin Penetration of a Copper Tripeptide (2010) in-vitro permeation (PMC) Li et al

Dont let this distract you from the obvious trade-off: Youll likely need significantly higher nasal doses to achieve comparable systemic effects to injectable formulations

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