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Chronic high-dose vitamin B intake (generally in gram quantities daily over many months) has been linked to severe sensory neuropathy characterized by numbness, impaired proprioception, and paresthesia in a stocking-glove distribution

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The literature reports that melatonin serum levels increase after HI, such as the endogenous neuroprotective response to brain injury 135

Recent studies have also demonstrated the importance of some amino acids on methionine metabolism ( Reference Brosnan, da Silva and Brosnan 14 , Reference Fukada, Shimada and Morita 33 )

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