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The amount of copper in most copper peptide serums is low enough that it shouldnt pose a major risk to most healthy people, but its still something to be mindful of.15 However, those with Wilsons disease a rare genetic condition may be best off avoiding copper peptide serums (or any skin care product containing copper), as the condition causes the element to build up in the body.16 Cancer risks GHK-Cu seemingly promotes angiogenesis, or the formation of new blood vessels.14 Though this can lead to beneficial outcomes like better wound healing, it may also lead to the growth or spread of cancer by giving solid tumors a blood supply.17 This means that if you have active or suspected cancer, it may be wise to avoid copper peptides

Some clinics may charge more because of their location while others located in urban areas are less accessible and therefore may demand higher prices

The small molecule size means it is able to travel deeper in the skin

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In September 2025, the Food and Drug Administration issued over 50 Warning Letters to companies for marketing compounded GLPs as generic versions or that make comparative claims to FDA-approved versions