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Phosphorylation of IGF-IR/InsR is elevated in ER+ breast cancer cells resistant to estrogen deprivation and tamoxifen, possibly due to increased secretion of IGF1/2 in these cells and elevated expression of retinoblastoma-binding protein 2 that inhibits IGFBP4/5 by interacting with ER-NRIP1-HDAC1 complex [107,108,109]

The peptide promotes fatty acid oxidation in skeletal muscle, enhancing the utilization of lipids as an energy source while sparing glucose for other metabolic processes

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The PDB ID for each protein is inbetween parentheses

GLP-1 receptor agonists and insulin both help manage blood sugar, but they work in very different ways, particularly in people with type 2 diabetes mellitus and obesity